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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARHGEF5 All Species: 12.42
Human Site: Y641 Identified Species: 30.37
UniProt: Q12774 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12774 NP_005426.2 1597 176799 Y641 R P P K P A I Y S S V T P R R
Chimpanzee Pan troglodytes XP_519460 1754 193086 T773 Y G F P S T G T S P P R P P A
Rhesus Macaque Macaca mulatta XP_001094223 1859 204116 Y904 R P P K P A I Y S S V T P R R
Dog Lupus familis XP_539834 1604 174905 Y651 R A P K P A I Y G S V I P R R
Cat Felis silvestris
Mouse Mus musculus Q8BWA8 802 88833
Rat Rattus norvegicus XP_001073085 1589 177312 Y636 R P P K T A I Y G S L I P R R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518302 453 52163
Chicken Gallus gallus XP_417225 1733 193947 F763 W G R T S T P F N Q P E G I P
Frog Xenopus laevis NP_001128552 856 97785
Zebra Danio Brachydanio rerio XP_697662 977 110044 I56 L L R Q H Q H I A V C Q Q E T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.5 80 60.1 N.A. 27.1 64.6 N.A. 22.5 35.2 28.4 28.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 88.1 81.9 67.7 N.A. 35.8 72.8 N.A. 25 49.1 38.3 39.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 100 80 N.A. 0 73.3 N.A. 0 0 0 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 100 80 N.A. 0 80 N.A. 0 13.3 0 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 0 40 0 0 10 0 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 10 0 10 0 % E
% Phe: 0 0 10 0 0 0 0 10 0 0 0 0 0 0 0 % F
% Gly: 0 20 0 0 0 0 10 0 20 0 0 0 10 0 0 % G
% His: 0 0 0 0 10 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 40 10 0 0 0 20 0 10 0 % I
% Lys: 0 0 0 40 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 10 0 0 0 0 0 0 0 0 10 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % N
% Pro: 0 30 40 10 30 0 10 0 0 10 20 0 50 10 10 % P
% Gln: 0 0 0 10 0 10 0 0 0 10 0 10 10 0 0 % Q
% Arg: 40 0 20 0 0 0 0 0 0 0 0 10 0 40 40 % R
% Ser: 0 0 0 0 20 0 0 0 30 40 0 0 0 0 0 % S
% Thr: 0 0 0 10 10 20 0 10 0 0 0 20 0 0 10 % T
% Val: 0 0 0 0 0 0 0 0 0 10 30 0 0 0 0 % V
% Trp: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 40 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _